Blar i ODA Open Digital Archive på forfatter "Molden, Espen"
-
Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine; Johnson, Line Kristin; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Åsberg, Anders; Molden, Espen; Robertsen, Ida (European Journal of Clinical Pharmacology;Volume 78, issue 8, Peer reviewed; Journal article, 2022-06-01)Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol (4βOHC) is a promising ... -
Effect of CYP2D6 genotype on duloxetine serum concentration
Hole, Kristine; Gangsø, Sofie; Jensstuen, Åse Tonette; Ormøy, Hanne Holte; Paulsen, Maren; Molden, Espen; Haslemo, Tore (Peer reviewed; Journal article, 2023)Duloxetine is metabolized by cytochrome P450 (CYP)1A2 and CYP2D6. The aim of this study was to investigate the effect of the CYP2D6 genotype on duloxetine serum concentration adjusting for age and sex. Patients were included ... -
Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo
Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kausberg, Marianne; Mæland, Sondre; Tveito, Marit; O'Connell, Kevin Sean; Molden, Espen; Kringen, Marianne K. (Current drug metabolism;Volume 23, Issue 1, Peer reviewed; Journal article, 2022)Background: Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact of various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on the exposure and metabolism of CLZ in vivo is ... -
Evidence for solanidine as a dietary CYP2D6 biomarker: Significant correlation with risperidone metabolism
Wollmann, Birgit Malene Tovik; Smith, Robert Løvsletten; Kringen, Marianne K.; Ingelman-Sundberg, Magnus; Molden, Espen; Størset, Elisabet (Peer reviewed; Journal article, 2023)Aims: The extensive variability in cytochrome P450 2D6 (CYP2D6) metabolism is mainly caused by genetic polymorphisms. However, there is large, unexplained variability in CYP2D6 metabolism within CYP2D6 genotype subgroups. ... -
Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes
Lao, Yvonne Elisabeth; Molden, Espen; Kringen, Marianne K.; Annexstad, Ellen Johanne; Sæverud, Håvard Andreassen; Jacobsen, Dag; Hovda, Knut Erik (Basic & Clinical Pharmacology & Toxicology;Volume 127, Issue 1, July 2020, Journal article; Peer reviewed, 2020-01-24)Paracetamol has a good safety profile, but pharmacogenetic differences in drug-metabolizing enzymes may have an impact on its risk of hepatotoxicity. We present a case of fatal acute liver failure (ALF) after therapeutic ... -
Genotyping av pasienter behandlet med selektive serotoninreopptakshemmere
Solhaug, Vigdis; Haslemo, Tore; Kringen, Marianne Kristiansen; Molden, Espen; Dietrichs, Erik Sveberg (Tidsskrift for Den norske legeforening;Utgave 13/2022 – Årgang 142, Peer reviewed; Journal article, 2022-09-26)Bakgrunn: Selektive serotoninreopptakshemmere (SSRI) brukes av over 180 000 mennesker i Norge. Enzymene CYP2D6 og CYP2C19 er sentrale i metabolismen av SSRI-antidepressiver. Serotonintransportøren kodet av SLC6A4 kan ha ... -
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits
O`Connell, Kevin; Smith, Robert Løvsletten; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Molden, Espen; Andreassen, Ole Andreas (Translational Psychiatry; 10, Article number: 198 (2020), Journal article; Peer reviewed, 2020-06-19)Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum ... -
Prediction of CYP2D6 poor metabolizers by measurements of solanidine and metabolites—a study in 839 patients with known CYP2D6 genotype
Wollmann, Birgit Malene Tovik; Størset, Elisabet; Kringen, Marianne K.; Molden, Espen; Smith, Robert Løvsletten (Peer reviewed; Journal article, 2023)Purpose Poor metabolizers (PMs) of the highly polymorphic enzyme CYP2D6 are usually at high risk of adverse effects during standard recommended dosing of CYP2D6-metabolized drugs. We studied if the metabolism of solanidine, ... -
Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients
Faraj, Pari; Størset, Elisabet; Hole, Kristine; Smith, Godfrey L; Molden, Espen; Dietrichs, Erik Sveberg (Peer reviewed; Journal article, 2023)Background For a decade, patients have been advised against using high citalopram- and escitalopram-doses due to risk for ventricular arrhythmia and cardiac arrest. Still, these drugs are widely used to treat depression ...